On Tuesday, the developers of cutting-edge Israeli nanotechnology devices announced that their “micro-needles” provide the same results for inoculations, yet use far less vaccine. NanoPass is sharing its proprietary MicronJet microneedle device with vaccine and immunotherapy companies to help in the efforts to develop a safe, effective and affordable vaccine against SARS-COV-2, novel coronavirus, according to a recent article published in the medical website OnDrugDelivery.com
Company Chief Executive Yotam Levin, MD, explained: “The skin contains specialised dendritic cells that process and induce strong immune responses – that’s why microneedle injections enable reduction of vaccine doses by five-fold, thereby reducing overall cost, required capacity and production time. We believe a reliable injection into the skin is critical for successful activation of broad and effective immune responses.”
Novel Coronavirus presents a global pandemic with unprecedented medical, economic and social scales. Since there is currently no proven antiviral therapy and herd immunity is likely months away, the race for finding a vaccine is in full swing on a global level. Considering this urgent need, NanoPass is joining forces with leading vaccine and immunotherapy companies around the world and is sharing its proprietary MicronJet microneedle device to enable development of a safe, effective and affordable vaccine.
The NanoPass’s device targets immune cells of the skin by harnessing the skin’s potent immune system to improve vaccines and/or to dramatically reduce the dose while achieving the same immunity. “The human skin is our first layer of defense against many infectious diseases,” says Yotam Levin, MD, Chief Executive Officer of NanoPass. “The skin contains specialised dendritic cells that process and induce strong immune responses – that’s why microneedle injections enable reduction of vaccine doses by five fold, thereby reducing overall cost, required capacity and production time. We believe a reliable injection into the skin is critical for successful activation of broad and effective immune responses, which should be explored for most injectable vaccines”.
The company’s technology is backed up by over 55 completed/ongoing clinical studies with various vaccines and vaccine platforms, including pandemic (H1N1, H5N1) and seasonal flu, live attenuated VZV vaccine, that have shown improved immunogenicity and significant dose-sparing. Preclinical evidence with mRNA and DNA vaccines showed promising results.
NanoPass has previously supported US CDC in a Phase III infant polio vaccination trial; with ITRC on PPD skin testing; in Type 1 diabetes immunotherapy; and supported NIAID with devices to evaluate immunogenicity of a pandemic flu vaccine; and multiple vaccine pharma.